A Phase I Study of Low Pressure Hyperbaric Oxygen Therapy for
Blast-Induced Post Concussion Syndrome and
Post Traumatic Stress Disorder.
Harch P, Andrews SR, Fogarty E, Amen DG, Pezzullo JC, Lucarini J, Aubrey C, Taylor DV, Staab P, Van Meter K.
Louisians State University School of Medicine, New Orleans, Medicine, 1816 Industrial Blvd, Harvey, Louisiana, United States, 70058, 504-366-1445, 504-366-1029; firstname.lastname@example.org.
This is a preliminary report on the safety and efficacy of 1.5 ATA HBOT in military subjects with chronic blast-induced mild-moderate traumatic brain injury (TBI)/post-concussion syndrome (PCS) and post-traumatic stress disorder (PTSD).
Method: 16 military subjects received forty 1.5 ATA/60 minute HBOTs in 30 days.
Symptoms, physical and neurological exams, SPECT brain imaging, neuropsychological and psychological testing were completed before and within one week after treatment.
subjects experienced reversible middle ear barotrauma (5)
transient deterioration in symptoms (4),
and reversible bronchospasm (1); one subject withdrew.
Post treatment testing demonstrated significant improvement in: