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Explore the therapeutic mechanisms and clinical applications of Hyperbaric Oxygen Therapy (HBOT) in treating neurological disorders, emphasizing the importance of tailored treatments based on pressure and hyperoxia doses.

Review of Hyperbaric Therapy & Hyperbaric Oxygen Therapy in the Treatment of Neurological Disorders According to Dose of Pressure and Hyperoxia

Edited by
Paul Gregory Harch, Enrico M. Camporesi, Dominic D’Agostino, John Zhang, George Mychaskiw II and Keith Van Meter

Published in
Frontiers in Neurology

Hyperbaric Oxygen Therapy (HBOT) is rapidly gaining attention for its potential to treat a wide range of neurological disorders, with ongoing research exploring the effects of specific pressure and oxygen doses. A recent comprehensive review, published in Frontiers in Neurology, delves into the therapeutic mechanisms and clinical applications of HBOT. The study highlights its role in mobilizing stem cells, reducing inflammation, and promoting recovery in conditions such as traumatic brain injuries, spinal cord decompression, and neurodegenerative diseases. By systematically analyzing dose-response relationships, this review underscores the importance of tailored hyperbaric treatments to maximize efficacy while minimizing risks.

For a deeper dive into this groundbreaking research and its implications for neurological therapies, learn more here.  

Explore the therapeutic mechanisms and clinical applications of Hyperbaric Oxygen Therapy (HBOT) in treating neurological disorders, emphasizing the importance of tailored treatments based on pressure and hyperoxia doses.
Figure 1. Sequential SPECT brain imaging of Subject #16 before the first HBOT (Row 0) then after 1, 40, 80 HBOTs, a 6-month break (Row R), 110 HBOTs, and 1 year post 110th HBOT (1 YR). Images are statistical parametric maps of selective coregistered slices. Color scheme: black indicates rCBF is within reference normal range. Increasing Z-scores (blood flow) are blue, green, orange, red, white on the left 3 columns and decreasing Z-scores with the same color scheme on the right 3 columns. SPECT at time 0 shows multiple areas of abnormally increased brain blood flow (top row left 3 images) and abnormally decreased brain blood flow (top row right 3 images) compared to normal and the other 6 patients in the study. Note intensification and broadening of Row R increased right frontal blood flow (6 months after 80th HBOT) that shows persistence and increases in the right frontal, posterior fronto-parietal and parietal, opposite anterior frontal, right temporal, and cerebellar areas after removal from the study for behavioral deterioration (Row 110), nearly all of which recede 1 year post study (1YR) to less than pre-HBOT levels (Row 0). Simultaneously, at 1YR post HBOT the right 3 panels show broadening of the adjacent areas with significant decreases in blood flow compared to the pre-HBOT level. Reproduced with permission Best Publishing Company (43).
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