HBOT in TBI References

Hyperbaric oxygen therapy is a treatment for wounds in the body in any location and of any duration.

In the past two decades it has been increasingly successfully applied to patients with chronic traumatic brain injury of all severities, first by myself ^1-9 and then by others.^10-16 The early human experience was duplicated in an animal model that constitutes the only improvement of chronic brain injury in animals in the history of science.¹⁷ The study was performed using the human protocol. In severe traumatic brain injury there are two controlled trials^11,12 and in mild traumatic brain injury post-concussion syndrome there are two randomized controlled trials.^14,16 All studies in chronic TBI done in this dosing range have shown positive results. This body of literature not only supports hyperbaric oxygen therapy for chronic neurocognitive residual of traumatic brain injury as a medical necessity, but also constitutes evidence-based medicine according to the definition of Sackett.¹⁸ In addition, there is no comparatively effective therapy.
Stated by Paul G. Harch, M.D.

Paul G. Harch, M.D. www.hbot.com Harch Hyperbarics, Inc

References:

1. Harch, P.G., Van Meter, K.W., Gottlieb, S.F., and Staab, P. (1994). HMPAO SPECT brain imaging and low pressure HBOT in the diagnosis and treatment of chronic traumatic, ischemic, hypoxic, and anoxic encephalopathies. Undersea Hyperb. Med. 21(Suppl), 30.
2. Harch, P.G., Van Meter, K.W., Neubauer, R.A., and Gottlieb, S.F. (1996). Use of HMPAO SPECT for assessment of response to HBO in ischemic/hypoxic encephalopathies, in: Appendix, Textbook of Hyperbaric Medicine, 2nd ed. K.K. Jain (ed.), Hogrefe and Huber Publishers: Seattle (WA), pps. 480-491.
3. Harch, P.G. and Neubauer, R.A. (1999). Hyperbaric Oxygen Therapy in Global Cerebral Ischemia/ Anoxia and Coma, in: Chapter 18, Textbook of Hyperbaric Medicine, 3^rd Revised Edition. K.K. Jain (ed.), Hogrefe and Huber Publishers: Seattle (WA), pps. 319-345.
4. Harch, P.G. (2002). The dosage of hyperbaric oxygen in chronic brain injury, in: The Proceedings of the 2^nd International Symposium on Hyperbaric Oxygenation for Cerebral palsy and the Brain-Injured Child. J.T. Joiner (ed.). Best Publishing Co: Flagstaff (AZ), pps. 31-56.
5. Harch, P.G. and Neubauer, R.A. (2004). Hyperbaric oxygen therapy in global cerebral ischemia/ anoxia and coma, in: Chapter 18, Textbook of Hyperbaric Medicine, 3^rd Revised Edition. K.K. Jain (ed.). Hogrefe and Huber Publishers: Seattle (WA), pps. 223-261.
6. Harch, P.G., and Neubauer, R.A. (2009). Hyperbaric oxygen therapy in global cerebral ischemia/anoxia and coma, in: Chapter 19, Textbook of Hyperbaric Medicine, 5^th Revised Edition. K.K. Jain (ed.), Hogrefe and Huber Publishers: Seattle (WA), pps. 235-274.
7. Harch, P.G., Neubauer, R.A., Uszler, J.M., and James, P.B. (2009). Appendix: Diagnostic Imaging and HBO Therapy, in: Chapter 44, Textbook of Hyperbaric Medicine, 5^th Revised Edition. K.K. Jain (ed.), Hogrefe and Huber Publishers: Seattle (WA), pps. 505-519.
8. Harch, P.G., Fogarty, E.F., Staab, P.K., and Van Meter, K. (2009). Low pressure hyperbaric oxygen therapy and SPECT brain imaging in the treatment of blast-induced chronic traumatic brain injury (post-concussion syndrome) and post-traumatic stress disorder: a case report. Cases Journal 2, 6538. http://casesjournal.com/casesjournal/article/view/6538.
9. Harch, P.G., Andrews, S.R., Fogarty, E.F., Amen, D., Pezzullo, J.C., Lucarini, J., Aubrey, C., Taylor, D.V., Staab, P.K., and Van Meter, K.W.. (2012). A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder. J Neurotrauma. 29, 168-185.
10. Neubauer, R.A., Gottlieb, S.F., and Pevsner, N.H. (1994). Hyperbaric Oxygen for Treatment of Closed Head Injury. South. Med. J. 87, 933-936.
11. Golden, Z.L., Neubauer, R., Golden, C.J., Greene, L., Marsh, J., and Mleko, A. (2002). Improvement in cerebral metabolism in chronic brain injury after hyperbaric oxygen therapy. Int. J. Neurosci. 112, 119-131.
12. Golden, Z., Golden, C.J., Neubauer, R.A. (2006). Improving neuropsychological function after chronic brain injury with hyperbaric oxygen. Disability and Rehabilitation. 28(22), 1379-86.
13. Wright, J.K., Zant, E., Groom, K., Schlegel, R.E., and Gilliland, K. (2009). Case report: Treatment of mild traumatic brain injury with hyperbaric oxygen. Undersea Hyperb. Med. 36, 391-99.
14. Wolf, G., Cifu, D.X., Baugh, L, Carne, W., Profenna, L. (2012). The effect of hyperbaric oxygen on symptoms following mild traumatic brain injury. J Neurotrauma 29(17), 2606-12.
15. Churchill, S., Weaver, L.K., Deru, K., Russo, A.A., Handrahan, D., Jr. Orrison, W.W., Foley, J.F., Elwell, H.A. (2013). A prospective trial of hyperbaric oxygen for chronic sequelae after brain injury (HYBOBI). Undersea Hyper. Med. 40(2), 165-193.
16. Boussi-Gross, R., Golan, H., Fishlev, G., Bechor, Y., Volkov, O., Bergan, J., Friedman, M., Hoofien, D., Shlamkovitch, N., Ben-Jacob, E., Efrati, S. (2013) Hyperbaric Oxygen Therapy Can Improve Post Concussion syndrome Years after Mild Traumatic Brain Injury-Randomized Prospective Trial. PLOS ONE 8, 1-18.
17. Harch, P.G., Kriedt, C., Van Meter, K.W., and Sutherland, R.J. (2007). Hyperbaric oxygen therapy improves spatial learning and memory in a rat model of chronic traumatic brain injury. Brain Res. 1174, 120-9. Epub 2007 Aug.
18. Sackett, D., Rosenberg, M.C., Gray, J.A.M., Haynes, R.B., and Richardson, W.S. (1996). Evidence based medicine: what it is and what it isn’t. BMJ 312, 71-2.